After January 12, Microsoft ends support for all versions of Internet explorer except the newer versions supplied with new versions of Windows.
After January 12, Microsoft will no longer provide security updates, technical support or hotfixes for .NET Framework versions 4, 4.5, and 4.5.1. To minimize risk in the environment, Microsoft says to upgrade to a known supported version. The supported versions are all other framework versions, including 3.5, 4.5.2, 4.6 and 4.6.1.
Microsoft ends support for Vista in April 2017.
Give us a call and we can help you ready your systems for these changes ahead.